Textiles are indispensable materials in many fields today, especially in clothing and home textiles. Textile surfaces and products are obtained through the use of different production techniques and various materials. Interior textiles include products such as curtains, carpets, upholstery fabrics, wall coverings, and accessories, and they are among the spatial components that play an important role in terms of the functionality and aesthetics of living spaces. Situations such as the use of synthetic fibers and chemical dyes in products create problems in terms of sustainability. In order to ensure sustainability, natural or recyclable materials and production techniques that are compatible with nature and the environment can be used. In this study, surface designs were created to be used in interior textile surfaces, inspired by the motifs and patterns in the Zeugma Museum located in the city of Gaziantep. The reason for selecting the Zeugma Mosaics as the subject is both to encourage the reinterpretation of local and cultural values within the framework of sustainable design, and to contribute to the transmission of the mosaics that have survived from the past to the present into the future with a different perspective. Surfaces, which were designed with digital and transfer printing techniques in mind on cotton and linen fabrics, were rendered onto various interior visuals through computer software. The printing methods were selected to be sustainable in order to minimize elements that may have negative effects on nature. It is considered that the fabric selection, the production method, and the theme preference intended to be used in the study will contribute to sustainability.