Targeting of cell mockups using sperm-shaped microrobots in vitro


Khalil I. S. M., TABAK A. F., Hosney A., Klingner A., Shalaby M., Abdel-Kader R. M., ...Daha Fazla

6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics, BioRob 2016, Singapore, Singapur, 26 - 29 Haziran 2016, cilt.2016-July, ss.495-501 identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 2016-July
  • Doi Numarası: 10.1109/biorob.2016.7523675
  • Basıldığı Şehir: Singapore
  • Basıldığı Ülke: Singapur
  • Sayfa Sayıları: ss.495-501
  • İstanbul Ticaret Üniversitesi Adresli: Hayır

Özet

Sperm-shaped microrobots are controlled under the influence of weak oscillating magnetic fields (milliTesla range) to selectively target cell mockups (i.e., gas bubbles with average diameter of 200 μm). The sperm-shaped microrobots are fabricated by electrospinning using a solution of polystyrene, dimethylformamide, and iron oxide nanoparticles. These nanoparticles are concentrated within the head of the microrobot, and hence enable directional control along external magnetic fields. The magnetic dipole moment of the microrobot is characterized (using the flip-Time technique) to be 1.4×10-11 A.m2, at magnetic field of 28 mT. In addition, the morphology of the microrobot is characterized using Scanning Electron Microscopy images. The characterized parameters and morphology are used in the simulation of the locomotion mechanism of the microrobot to prove that its motion depends on breaking the time-reversal symmetry, rather than pulling with the magnetic field gradient. We experimentally demonstrate that the microrobot can controllably follow S-shaped, U-shaped, and square paths, and selectively target the cell mockups using image guidance and under the influence of the oscillating magnetic fields.